REVIEW PAPER
Candida albicans as the main etiological factor in vulvovaginal candidiasis with consideration of the impact of hormonal contraception. Review
 
More details
Hide details
1
The Academy of Applied Medical and Social Sciences, Poland
 
These authors had equal contribution to this work
 
 
Submission date: 2025-12-16
 
 
Acceptance date: 2026-01-28
 
 
Online publication date: 2026-04-28
 
 
Publication date: 2026-02-15
 
 
Corresponding author
Jacek Perliński   

The Academy of Applied Medical and Social Sciences, Lotnicza 2, 82-300, Elblag, Poland
 
 
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Vulvovaginal candidiasis (VVC) is considered the most frequent fungal infection affecting women of reproductive age. In more than 85% cases, the etiological factor is Candida albicans, while less frequently other species, such as C. glabrata or C. tropicalis are involved. The purpose of this article is to present the risk factors for developing VVC, the virulence factors of the pathogen, and an analysis of the impact of hormonal contraception on the incidence of infections. Literature shows that hormones, which are the main component of the contraceptives, significantly affect the vaginal microbiota – leading to a reduction in the population of Lactobacillus species and thereby facilitating the colonisation of C. albicans. Population studies confirm that a higher incidence of VVC is observed among women using hormonal contraception, compared to those who do not.

Aim:
Existing reaserch highlights the necessity of monitoring the vaginal microbiota in female patients using hormonal contraceptives, and for considering prophylaxis when selecting contraceptive methods.

Material and methods:
The investigation entails a systematic review executed by exploring primary articles within databases, including PubMed, Semantic Scholar, Medline, Scopus, Science Direct, and EBSCO.

Results and discussion:
The confirming articles 17. The denying articles 4.

Conclusions:
Women using hormonal contraception should remain alert and seek professional advice if characteristic symptoms occur.
FUNDING
None declared.
CONFLICT OF INTEREST
No conflict of interest have been implied. Every information written above is based on the sources stated in the references.
REFERENCES (21)
1.
Srb N, Talapko J, Meštrović T, et al. A Comprehensive Overview of Candida albicans as the Leading Pathogen in Vulvovaginal Candidiasis. J Fungi (Basel). 2025;11(9):632. https://doi.org/10.3390/jof110....
 
2.
Jasim S, et al. The relationship between vulvovaginal candidiasis and some predisposing factors in prevalence among Baghdad women. Sys Rev Pharm. 2020;11(12):1318–1322. https://doi.org/10.13140/RG.2.....
 
3.
Pereira LC, Correia AF, da Silva ZDL, et al. Vulvovaginal candidiasis and current perspectives: new risk factors and laboratory diagnosis by using MALDI TOF for identifying species in primary infection and recurrence. Eur J Clin Microbiol Infect Dis. 2021;40(8):1681–1693. https://doi.org/10.1007/s10096....
 
4.
4 Salih R, Haddad A, Hassan A. Prevalence of vulvovaginal Candidiasis and its association with contraceptives. AVFT. 2021;40(4):373–376. https://doi.org/10.5281/zenodo....
 
5.
Sasani E, Rafat Z, Ashrafi K, et al. Vulvovaginal candidiasis in Iran: A systematic review and meta-analysis on the epidemiology, clinical manifestations, demographic characteristics, risk factors, etiologic agents and laboratory diagnosis. Microbiol Pathog. 2021;154:104802. https://doi.org/10.1016/j.micp....
 
6.
Wei T, Wang H, Wen B. Comparison of copper IUDs and hormonal IUDs in prevalence of Candida species in cervicovaginal smears. Cell Mol Biol (Noisy-le-grand). 2022;67(4):130–134. https://doi.org/10.14715/cmb/2....
 
7.
Fernandes Â, Azevedo N, Valente A, et al. Vulvovaginal candidiasis and asymptomatic vaginal colonization in Portugal: Epidemiology, risk factors and antifungal pattern. Med Mycol. 2022;60(5):myac029. https://doi.org/10.1093/mmy/my....
 
8.
Alsudani AA, Al-Awsi GRL. Detection of candida spp. That causes vulvovaginitis in women that use contraceptive methods. Wiad Lek. 2022;75(8 Pt 2):1965–1969. https://doi.org/10.36740/Wlek2....
 
9.
Lillian A, Chuku A, Joseph N, Ajide B, Reuben R, Akwashiki O. Phylogenetic diversity and susceptibility of Candida species from women using contraceptive devices in Central Nigeria. Int J Infect Dis. 2022;116(Suppl):S5–S6. https://doi.org/10.1016/j.ijid....
 
10.
Irene VR, Sajeeth CI, Karthikeyan V, Sabitha J. Assessment of risk factors for developing vulvovaginal candidiasis among women at various age groups. Biosci Biotech Res Asia. 2023;20(1):359–365. https://doi.org/10.13005/bbra/....
 
11.
Subedi A, Upreti MK, Rana JC, Sapkota RP, Thapa Shrestha U. Vulvovaginal candidiasis, an increasing burden to women in the tropical regions attending Bharatpur Hospital, Chitwan. J Mycol Med. 2024;34(4):101509. https://doi.org/10.1016/j.mycm....
 
12.
Bahat AA, Murtiastutik D, Setyaningrum T, Listiawan MY, Sawitri, Utomo B. The association between vulvovaginal candidiasis and hormonal contraceptive use in the outpatient clinic of Dr Soetomo Hospital, Surabaya in 2017–2020: A retrospective study. J Pak Assoc Dermatol. 20241;34(2):374–83. https://doi.org/10.66344/jpad.....
 
13.
Hussen I, Aliyo A, Abbai MK, Dedecha W. Vaginal candidiasis prevalence, associated factors, and antifungal susceptibility patterns among pregnant women attending antenatal care at bule hora university teaching hospital, Southern Ethiopia. BMC Pregnancy Childbirth. 2024;24(1):619. https://doi.org/10.1186/s12884....
 
14.
Aklilu A, Woldemariam M, Manilal A, et al. Aerobic vaginitis, bacterial vaginosis, and vaginal candidiasis among women of reproductive age in Arba Minch, southern Ethiopia. Sci Rep. 2024;14(1):9813. https://doi.org/10.1038/s41598....
 
15.
M'Mebwa Mtende L, Kasujja M, Simba L, et al. Factors associated with vulvovaginal candidiasis and antifungal susceptibility patterns among nonpregnant women attending the gynecology clinic at Hoima Regional Referral Hospital: a cross-sectional study. 2024. https://doi.org/10.21203/rs.3.....
 
16.
Karam K, Arceneaux A, Vincent K, Pyles R. Risks of infections with contraceptive vaginal rings compared to no hormone use. Obstet Gynecol. 2024;143:71S–71S. https://doi.org/10.1097/01.AOG....
 
17.
Wood S, Traub C, Karam K, Golovko G, Vincent K. Risks of vaginal and sexually transmitted infections with copper intrauterine devices compared to oral contraceptives. Obstet Gynecol. 2025;145:44S–44S. https://doi.org/10.1097/AOG.00....
 
18.
Omran EA, Youssef NES, Abdelfattah AH, Esmail SA, Fouad AM. Copper IUD increases virulence of non-albicans Candida species isolated from women with vulvovaginal candidiasis. Eur J Contracept Reprod Health Care. 2020;25(2):120–125. https://doi.org/10.1080/136251....
 
19.
Bakus C, Budge K, Feigenblum N, Figueroa M, Oladipo A. The impact of contraceptives on the vaginal microbiome in the non-pregnant state. Front Microbiomes. 2023;1:1055472. https://doi.org/10.3389/frmbi.....
 
20.
Wrønding T, Mollerup S, Troen Lundsgaard A. O-277 Exploring the relationship between the vaginal microbiota and vaginal symptoms. Hum Reprod. 2024;31(Suppl 1). https://doi.org/10.1093/humrep....
 
21.
Rosati D, Ricaño Ponce I, Omosa-Manyonyi GS. Plasma Inflammatory Proteome Profile in a Cohort of Patients with Recurrent Vulvovaginal Candidiasis in Kenya. J Fungi (Basel). 2024;10(9):638. https://doi.org/10.3390/jof100....
 
ISSN:1730-9980
Journals System - logo
Scroll to top